Advances in Perinatal Thyroidology by Leslie J. DeGroot (auth.), Barry B. Bercu, Dorothy I.

By Leslie J. DeGroot (auth.), Barry B. Bercu, Dorothy I. Shulman (eds.)

Perinatal difficulties in thyroid gland body structure are universal yet complex and current a diagnostic hassle for the first clinician. In December 1990, a world staff of uncomplicated and scientific investigators collected in Longboat Key, Florida to handle those matters. The individuals incorporated internists, obstetricians, pedia­ tricians, neurologists, pathologists and uncomplicated scientists in mobile metabolism, endocrine body structure, and molecular biology. The displays contained inside this booklet assemble their most present and very important learn with regards to the sector of perinatal thyroidology. This booklet is predicated at the dynamic and fruitful trade of the members on the symposium. we're indebted to those participants whose worthy insights and efforts are contained inside this article. Barry B. Bercu Dorothy I. Shulman vii CONTENTS consultation I Mechanism of Thyroid Hormone motion 1 Leslie J. DeGroot Thyroid procedure Ontogeny within the Sheep: A version for Precocial Mammalian Species • . . • • eleven Delbert A. Fisher Pathologic stories of Fetal Thyroid 27 improvement • • • • • • • Douglas R. Shanklin Thyroid Hormone regulate of mind and Motor improvement: Molecular, Neuroanatomical, forty seven and Behavioral experiences • • • • • • • S. A. Stein, P. M. Adams, D. R. Shanklin, G. A. Mihailoff, and M. B. Palnitkar The Thyroidectomized Pregnant Rat: An Animal version to check Fetal results of Maternal Hypothyroidism 107 Susan P. Porterfield and Chester E.

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Thyroid folliculogenesis in second half of human gestation, a period of organ maturation and relatively rapid fetal growth. GAR 25-28 weeks. Birth weight 640 g, lived 43 days. Twinned with a grade 1 chorioma. Varied follicles with some retained colloid. Lesser survivals in this maturity class often have more colloid, suggesting a depletion or drawing down effect due to the principal intercurrent and ultimately fatal disease. Ventilator lung disease with multiple small and large lung abscesses. Hematoxylin and eosin stain.

The combined data has provided an important overview of mammalian thyroid ontogenesis. However the picture remains unfinished. We have limited insights into the maturation of the molecular events of hypothalamic pituitary control, the maturation of TSH and thyroid nuclear receptors and postreceptor events, and the mechanisms of the thyroid effects on brain maturation. We can look forward to continuing contributions in these areas. References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Fisher DA, Dussault JH, Sack J, Chopra IJ.

The maternally hypothyroid rat, produced by maternal thyroidectomy prior to conception, and its progeny simulate this human condition(Porterfield et aI, 1981; Morreale de Escobar et aI, 1983, 1985; Hadjzadeh et al, 1990). Both the iodine deficient rat and the maternal hypothyroid rat must be distinguished from the maternally hypothyroid rat that is produced by pharmacological intervention with PTU or methimazole or radioactive iodine(Legrand et aI, 1982-3). This model does THYROID CONTROL OF BRAIN AND MOTOR DEVELOPMENT ......

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