Alcohol and Opiates. Neurochemical and Behavioral Mechanisms by Kenneth Blum

By Kenneth Blum

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Extra resources for Alcohol and Opiates. Neurochemical and Behavioral Mechanisms

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Acetaldehyde, an inhibitor of the enzymatic oxidation of 5-hydroxyindoleacetaldehyde. Biochem. Pharm. 25:535-538 (1969). , Ungar, F. and Alivisatos, S. G. : Aldehyde derivatives of indoleamines and the enhancement of their binding onto brain macromolecules by pentobarbital and acetaldehyde. Nature New Biology 238(82): 126-128 (1972). Korsten, M. , Lieber, C. : High blood acetaldehyde levels after ethanol administra­ tion difference between alcoholic and non-alcoholic sub­ jects. New Eng. J. Med.

The contradictions within these studies are probably due to the nonequivalence of the symp­ toms examined by the various authors (21,23). Thus, while the studies of Goldstein (21) and Blum (22) indicated that catecholaminergic neurons may play a determinant role in producing convulsions due to handling (11) in mice undergoing withdrawal, the studies of Collier (23) indicate a primary role for serotonergic systems in determining withdrawal symptomatology. However, Collier (23) monitored head twitch­ ing as a primary measure of withdrawal.

Biochem. Pharmacol. 15:711-721 (1966). Videla, L. : Factors that modify the metabolism of ethanol in rat liver and adaptive changes produced by its chronic administration. Biochem. J. 110:275-281 (1970). Pohorecky, L. : Effects of ethanol on central and brain and heart. Acta. 34. 6 A:97- 109 (1968). Aghajanian, G. , Graham, A. W. and Sheard, M. : Serotonin-containing neurons in brain: Depression of firing by MAO inhibitors. Science 169:1100-1102 (1970). Hunt, W. A. : Alterations in the turnover of brain norepinephrine and dopamine in alcohol-dependent rats.

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