Biotransformations : a survey of the biotransformations of by D R Hawkins

By D R Hawkins

Now in its 7th striking quantity, Biotransformations has develop into tested as a special and significant resource for these occupied with the invention and improvement of recent compounds. It commonly covers the medical literature for the interval 1987 to 1994. The sequence presents a whole survey of the biotransformations, in vertebrates, of the subsequent: prescription drugs; agrochemicals; meals ingredients; environmental chemical compounds; business chemical substances. Biotransformations presents a prepared means of getting access to info at the recognized pathways for the biotransformation of structurally-related compounds. Key sensible teams supply an index-related process for retrieving info on compounds of curiosity. an additional index permits the retrieval of examples of particular biochemical reactions that may have wider program. every one quantity corresponds approximately with the clinical literature released in the course of a calendar 12 months. each one quantity includes a assessment bankruptcy which discusses examples of novel biotransformations, species variations, stereochemical features and mechanisms of toxicity linked to particular biotransformations. learn more... summary: Now in its 7th remarkable quantity, Biotransformations has turn into demonstrated as a different and significant resource for these serious about the invention and improvement of recent compounds. It extensively covers the clinical literature for the interval 1987 to 1994. The sequence presents a whole survey of the biotransformations, in vertebrates, of the subsequent: prescribed drugs; agrochemicals; meals ingredients; environmental chemical compounds; business chemical compounds. Biotransformations presents a prepared method of gaining access to details at the recognized pathways for the biotransformation of structurally-related compounds. Key practical teams offer an index-related process for retrieving details on compounds of curiosity. one other index permits the retrieval of examples of particular biochemical reactions that may have wider software. every one quantity corresponds approximately with the clinical literature released in the course of a calendar yr. each one quantity incorporates a overview bankruptcy which discusses examples of novel biotransformations, species ameliorations, stereochemical points and mechanisms of toxicity linked to particular biotransformations

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It was demonstrated that co-administration of Na;’SO4 to rats resulted in incorporation of 3sS into the sulfonic acid metabolite and proposed that this involved addition of sulfite, produced by microbial reduction to sulfate, to a cyclopentadienone. 11 A n unusual series of sulfonic acid metabolites are also formed from the herbicide S-23121 (86) in rats (p. 154). Three of these metabolites (87)-(89) were phenols derived by 0-dealkylation and addition of sulfite to the double bond. These polar metabolites were isolated from faeces and it was found that the sulfonic acid group was also radiolabelled when sodium [35S]sulfate was co-administered.

C H 4 H \O/ \O/ Selenium compounds are being investigated as cancer chemoprevention agents. The fate of selenite and methylated selenium compounds has been investigated in rats (p. 436). Inorganic selenium was excreted in urine as mono-, di- and tri-methylselenium. Dimethyl selenoside (26) was excreted in urine mainly as dimethylselenium (27). Trimethylselenonium (28) was excreted mainly unchanged but with small amounts of dimethylselenium. Evidence was obtained that methylated selenium compounds underwent both methylation and demethylation.

HPLC analysis of the adducts showed that the major components present were the syn- and anti-trihydroxy-products (4) and (9, the structures of which were confirmed by co-chromatography. The use of synthetic standards as intermediates showed that formation of the 11,12-dio1-13,14-epoxide(3) via the 11,12-dihydrodiol (4) was the key pathway involved in DNA adduct formation. Reference S. L. Ralston, H. H. S. Lau, A. Seidel, A. Luch, K. L. Platt and W. M. , 1994, 54, 887. 25 OH / / 1,2-Dihydronaphthalene, 1,2-Dihydroanthracene Use/occurrence: Model compounds Key functional groups: Dihydroarene Test system: Rat liver microsomes and purified cytochrome P-450 enzymes Structure and biotransformation pathway (4) Both 1,2-dihydronaphthalene (1) and 1,2-dihydroanthracene (2) were hydroxylated by rat liver microsomes and purified cytochrome P-450 enzymes to yield the metabolites (3) and (4).

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