Frontiers in Bioactive Lipids by Paul A. Grimaldi, Danielle Gaillard, Hidekuni Inadera, Lydia

By Paul A. Grimaldi, Danielle Gaillard, Hidekuni Inadera, Lydia Teboul, Gérard. Ailhaud (auth.), Jack Y. Vanderhoek (eds.)

Fatty Acids and Esters. Molecular Mechanisms occupied with the Adipogenic motion of Fatty Acids; P.A. Grimaldi, et al. Acyl Coenzyme A Synthetase and the shipping of Long-Chain Fatty Acids; P.N. Black.Lipid Binding Proteins. Structural and practical reviews at the middle Fatty Acid-Binding Protein; J.H. Veerkamp, C.F.M. Prinsen. The position of Intracellular Fatty Acid-Binding Proteins in mobile delivery of Fatty Acids; J. Storch, et al.Eicosanoid Biosynthetic Enzymes. Compartmentation of Prostaglandin Biosynthetic Enzymes; W.L. Smith, etal. Differential keep an eye on of Cyclooxygenase Catalysis in PGH Synthase Isoforms: position of Hydroperoxide Initiator; R.J. Kulmacz, et al.Eicosanoids and Receptors. Aspirin Switches Biosynthetic Circuits Triggering Novel Eicosanoids in the course of Cell-Cell Interactions which are effective Inhibitors of Neutrophil Migration and Tumor phone Proliferation; C.N. Serham, J. Claria.Sphingolipids. The function of Ceramide within the mobile pressure reaction; G.S. Dbaibo, et al.Phospholipids. Lysophosphatidic Acid-Induced signs in Astrocytes; J.N. Keller, et al.Phospholipases/Kinases. Discrimination among quite a few Phospholipase D actions within the Human Neutrophil and Their Relative Involvement in Oxidative Burst; V. Planat, et al. 28 extra Articles. Index.

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Unfortunately, the review examined clinical consequences with little attention to the amount of dietary linoleate against which the n-3 supplements were competing. The current 26 heavy "pressure" of dietary linoleate in the USA seems likely to diminish the success of such expensive and time-consuming clinical studies. Jnvestment of increasingly scarce clinical research funds needs more careful prospective assessment of the consequence of an imprecisely determined balance in the essential fatty acids.

1-8. Nutr. 61(suppl): 721S-725S. , 199Oa, Changing dietary patterns, Am. J. Clin. Nutr. 51: 991-993. , 1982, Selective incorporation of polyunsaturated fatty acids into phosphatidylcholine by rat liver microsOOlC8, J. BioI. , 257, 14968-14972. , Schmeisser, D. , and Burns, J. , 1992, Maintenance of lower proportions of n-6 eicosanoid precursors in phospholipids of human plasma in response to added dietary n-3 fatty acids, Biochim. Biophys. Acta 1180: 147-162. , 1990b, The Influence of Dietary Polyunsaturated Fats on the Composition of Fatty Acids in Rat Tissues, Lipids, 25, 505-516.

1990b; Lands et al, 1992). These empirical equations summarize many metabolic interactions in a way that predicts likely changes in fatty acid composition and that indicates the probable intensity of evoked eicosanoid responses. The equations employ the proportion of 20:3+20:4n-6 present among the 20 and 22-carbon highly unsaturated fatty acids (HUFA) of tissue phospholipids as a useful index of the intensity expected for eicosanoid-mediated responses. , 1992). ~ +~+~+~+~ ':n~' +~) Figure 1. , 1992).

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