IL-17, IL-22 and Their Producing Cells: Role in Inflammation by Franco Di Padova M.D., Bernhard Ryffel M.D., Valerie

By Franco Di Padova M.D., Bernhard Ryffel M.D., Valerie Quesniaux Ph.D. (auth.), Valérie Quesniaux, Bernhard Ryffel, Franco Padova (eds.)

The wisdom of Th17 cells and different mobile populations which secrete IL-17A, and/or IL-22 has accelerated significantly because the e-book of the 1st variation “Th17 Cells: position in irritation and Autoimmune ailment” in 2008. the current quantity has been thoroughly revised with the addition of latest chapters at the IL-17 receptor kinfolk and signaling, and an in-depth assessment of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells in addition to the plasticity of Th17 cells is mentioned. The position of IL-22 in cutaneous irritation together with psoriasis has been reviewed. additionally, the quantity includes severe updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse types for mechanistic reviews. finally, the newest medical development in neutralizing antibodies to IL-17A, IL-17RA not just confirms the healing promise foreseen in 2008, but in addition improves our wisdom of the pathogenesis of autoimmune illnesses. In precis, it is a well timed replace and demanding overview of the scientific and experimental features of IL-17, IL-22 and their generating cells.

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Exp Dermatol 16:779–798 105. Sabat R, Wolk K (2011) Research in practice: IL-22 and IL-20: significance for epithelial homeostasis and psoriasis pathogenesis. J Dtsch Dermatol Ges 9:518–523 106. Ma HL, Liang S, Li J, Napierata L, Brown T, Benoit S, Senices M, Gill D, DunussiJoannopoulos K, Collins M et al (2008) IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest 118:597–607 107. Besnard AG, Sabat R, Dumoutier L, Renauld JC, Willart M, Lambrecht B, Teixeira MM, Charron S, Fick L, Erard F et al (2011) Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A.

These effects are described now in more detail: IL-22 enhances the innate immunity of keratinocytes by strong upregulation of the expression of numerous antimicrobial molecules like the b-defensin (BD) 2 and IL-22 and IL-17: An Overview 23 Early Phase Late Phase Bacteria Antimicrobial peptides Antimicrobial peptides DC Phagocytosis MC IL-22 IL-22 N MF IL-17 IFN- g IL-23 L TNF-a, IL-1b Chemokines T IL-22 IL-17 IL-6 TNF-a, IL-1b, Chemokines Chemokines CD54 Selectines CD54 Chemokines FB MMPs G-CSF, GM-CSF, SCF Chemokines Fig.

These animals exhibited delayed onset, reduced maximum severity scores, ameliorated histological changes, and early recovery [88, 143]. Interestingly, IL-17A, but not IL-17F, seems to play an important role in the development of experimental contact delayed-type hypersensitivity, airway hypersensitivity, arthritis, and EAE [88, 144]. The role of IL-17 in experimental colitis in mice is less clear. It was described that IL-17F deficiency resulted in reduced DSS colitis, whereas IL-17A deficiency or neutralization caused more severe colitis [144, 145].

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