By Sarah E. Coupland (auth.), Arun D. Singh (eds.)
This ebook – a conjoint attempt of ocular oncologists, common oncologists, and pathologists – is a entire resource of authoritative info just about ocular and adnexal lymphoma. It covers all elements, together with scientific positive factors, class, epidemiology, diagnostic overview, biopsy ideas, histology and molecular pathology, staging tactics, and therapy tools. exact details is supplied on basic vitreoretinal and adnexal lymphomas and chapters also are integrated on infrequent variations akin to T mobilephone lymphoma and reactive lymphoid hyperplasia of the ocular adnexa. The emphasis all through is on effortless clarity, and the format guarantees swift retrieval of knowledge. so one can show basic suggestions, quite a few tables,clinical pictures, histopathologic microphotographs, and imaging stories (fluorescein and indocyanine angiograms, ultrasonograms, CT scans, and MR photographs) are incorporated.
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Extra info for Ocular and Adnexal Lymphoma
15 Molecular Genotyping Molecular genetics of ocular lymphoma is a relatively new and rapidly advancing field. Over the last decade or so, the use of genetic profiling in ocular lymphomas has enabled the delineation of genetics of specific ocular lymphoma subtypes, revealing both favorable and unfavorable characteristics and allowing a greater understanding of the pathogenic mechanisms that result in the development of lymphoma within the ocular compartment. Of the ocular adnexal lymphomas, MALT lymphoma is by far the most common subtype, making up more than 50 % of lymphomas diagnosed in the ocular compartment (Cho et al.
The main pitfalls of using FC are that architectural features cannot be assessed and occasionally the presence of an aberrant phenotype can be veiled by the normal cell population in the suspension diluting the neoplastic population. Nonspecific staining can be mistakenly interpreted as normal, whereby it masks specific staining, or conversely be judged as positive for a neoplastic proliferation when it is not the case. 2 Cytokine Analysis Differential expression of cytokines in neoplastic versus inflammatory processes has been the basis of many recent studies revealing that the ratio of interleukin IL-10 to IL-6 in vitreous fluid can help determine between the two processes (Buggage et al.
Br J Ophthalmol 73(10):846–851 cytoplasm. , CD5+, cyclinD1+ (illustrated in c), SOX-11+ (in d), and monotypical for IgD, in the absence of CD23 and CD10 (in most cases) Bi Y, Zeng N, Chanudet E et al (2012) A20 inactivation in ocular adnexal MALT lymphoma. Haematologica 97(6):926–930 Chan CC (2003b) Molecular pathology of primary intraocular lymphoma. Trans Am Ophthalmol Soc 101:275–292 Chan CC, Rubenstein JL, Coupland SE et al (2010) Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium.