By Alton Meister
Advances in Enzymology and similar parts of Molecular Biology is a seminal sequence within the box of biochemistry, supplying researchers entry to authoritative experiences of the newest discoveries in all parts of enzymology and molecular biology. those landmark volumes date again to 1941, delivering an unmatched view of the ancient improvement of enzymology. The sequence deals researchers the newest figuring out of enzymes, their mechanisms, reactions and evolution, roles in complicated organic technique, and their program in either the laboratory and undefined. each one quantity within the sequence gains contributions through best pioneers and investigators within the box from world wide. All articles are rigorously edited to make sure thoroughness, caliber, and clarity.
With its wide variety of issues and lengthy old pedigree, Advances in Enzymology and comparable parts of Molecular Biology can be utilized not just via scholars and researchers in molecular biology, biochemistry, and enzymology, but additionally by means of any scientist attracted to the invention of an enzyme, its houses, and its applications.
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Extra info for Advances in Enzymology and Related Areas of Molecular Biology, Volume 5
8 (155). The necessity of calcium for the conversion of prothrombin to thrombin by the thromboplastic factor has given rise to many explanations. Quick (171) has sought to show that prothrombin contained calcium in its molecule. Other workers (108, 138) assign a purely catalytic function to this cation. The final decision will have to await the analyses of pure prothrombin. It is possible that experiments with radioactive calcium could contribute to a solution of this problem. A discussion of methods for the determination of the prothrombin level in blood will be found in several recent monographs (16, 173).
Other Substances with Activating or Coagulating Properties In the following discussion it will be preferable to distinguish between substances having an activating effect on prothrombin and those that are themselves thrombin-like in action. The most interesting substance, as far as a thromboplastic effect is concerned, probably is trypsin. That blood, even in the presence of oxalate (loo), could be clotted by this enzyme has long been known (56). The same effect was later demonstrated for crystalline trypsin (164).
And Price, W. , 133, 1 (1940). Lauffer, M. , and Stanley, W. , 123,507 (1938). Lauffcr, hl. ,and Stanley, W. , 135,463 (1940). ,and Stanley, W. ,Arch. , 2,413 (1943). , and Stanley, W. , J . Biol. , 118,269 (1937). Lawrence, A. S. , J . Gen. , 27, 201 Lea, D. , and Smith, K. , Parasitology, 32,405(1940). ,J . Biol. , 128, lxi (1939). , 130,251 (1939). ,J . Gen. , 23, 719 (1940). , 25, 497 (1942). ,and Stanley, W. , J . Biol. , 117,733(1937). ,Lauffer, M. , and Stanley, W. , Nature, 142,841 (1938).