Controlled Drug Delivery. Designing Technologies for the by Kinam Park

By Kinam Park

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Ch003 2 HO Figure 3. Chemical representation of chitosan Table I. 5 (6) 1 max (n) NOTE: Pharmacokinetic parameters after intraduodenal administration of buserelin (500μg/rat). D. for the number of animals indicated (n). d. not determined. Reproduced with permissionfromreference 5. Copyright 1996 Pharm. Res. Another characteristic of this polymer is its mucoadhesion. It has been demonstrated, in repeated adhesion studies, that chitosan is fairly mucoadhesive in comparison to polycarbophil (8). Chitosan has been observed to promote the nasal absorption of insulin in rats and sheep (9).

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