Ciba Foundation Symposium 71 - Blood Cells and Vessel Walls:

Content:
Chapter 1 Chairman's advent (pages 1–2): J.L. Gowans
Chapter 2 The Haemopoietic Microenvironment of Bone Marrow: An Ultrastructural examine of the Interactions of Blood Cells, Stroma and Blood Vessels (pages 3–19): Leon Weiss
Chapter three Immunoelectron?Microscopic Characterization of Lymphoid Microenvironments within the Lymph Node and Thymus (pages 21–37): Willem Van Ewijk
Chapter four Structural and practical Differentiation of Microvascular Endothelium (pages 39–60): Maya Simionescu
Chapter five Haemodynamic and Biochemical Interactions in Intravascular Platelet Aggregation (pages 61–77): G.V.R. Born
Chapter 6 Prostacyclin (pages 79–111): J.R. Vane and S. Moncada
Chapter 7 The functionality and Pathways of Lymphocyte Recirculation (pages 113–126): J.L. Gowans and H.W. Steer
Chapter eight Reassortment of mobile Populations in the Lymphoid gear of the Sheep (pages 127–144): Wendy Trevella and Bede Morris
Chapter nine Lymphocyte Recirculation within the Sheep Fetus (pages 145–166): R.N.P. Cahill, I. Heron, D.C. Poskitt and Z. Trnka
Chapter 10 Lymphocyte site visitors via Lymph Nodes in the course of mobilephone Shutdown (pages 167–195): Ian McConnell, John Hopkins and Peter Lachmann
Chapter eleven impact of dermis portray with Oxazolone at the neighborhood Extravasation of Mononuclear Cells in Sheep (pages 197–209): J.G. Hall
Chapter 12 Metabolic reviews of High?Walled Endothelium of Postcapillary Venules in Rat Lymph Nodes (pages 211–241): P. Andrews, W.L. Ford and R.W. Stoddart
Chapter thirteen Adherence of Lymphocytes to the excessive Endothelium of Lymph Nodes in vitro (pages 243–263): Judith J. Woodruff and Barry J. Kuttner
Chapter 14 mobile, Genetic, and Evolutionary points of Lymphocyte Interactions with High?Endothelial Venules (pages 265–286): Eugene C. Butcher and Irving L. Weissman
Chapter 15 Macrophages and the Differential Migration of Lymphocytes (pages 287–298): J.H. Humphrey
Chapter sixteen Polymorphonuclear Leucocyte Chemotaxis: Detection of the Gradient and improvement of mobilephone Polarity (pages 299–311): Sally H. Zigmond
Chapter 17 Dynamic concept of Leucocyte Adhesion (pages 313–341): Peter D. Richardson
Chapter 18 Summing UP (pages 343–347): Irving L. Weissman

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On entering the parenchyma, T and B cells segregate and migrate towards their respective microenvironments (Gutman & Weissman 1973). T and B cells may leave the node by entering trabecular and medullary sinuses connected to the efferent lymphatic vessel. IK lymphocytes from the HEV towards the nodal parenchyma and their recirculation towards the lymph, we examined the cell surface topography of T a n d B cells in HEV, in medullary sinuses and in efferent lymphatics. Fig. 1 shows the morphology of a n HEV as observed with SEM.

The distribution of electrostatic charges on the blood front of the capillary endothelium indicates that even more refined local differentiation exists: (a) the cell membrane is negatively charged; (b) the diaphragms of vesicles and those of transendothelial channels lack anionic sites; (c) fenestral diaphragms are heavily loaded with anionic sites. Experiments with proteolytic enzymes suggest that these acidic sites on the fenestral diaphragms are primarily glycosaminoglycans, most likely heparan sulphate.

0Excerpta Medica 1980 39 Blood cells and vessel walls: functional interactions (Ciba Foundation symposium 71) p 39-60 40 M A Y A SIMIONESC'U From physiological experiments with graded dextrans (Pappenheimer et al 1951, Grotte 1956) the existence has been postulated of water-filled channels or pores within the capillary wall through which massive transport of macromolecules from plasma to interstitial fluid takes place. Two sets of pores have been suggested: the small and large pores (Landis & Pappenheimer 1963).

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