Corneal Angiogenesis: A Comprehensive Critical Review by Gordon K. Klintworth M.D., Ph.D. (auth.)

By Gordon K. Klintworth M.D., Ph.D. (auth.)

In this examine monograph, the famous pupil Dr. Gordon ok. Klintworth brings jointly the entire on hand details at the pathogenesis of corneal neovascularization. This booklet might be a useful contribution to the clinical literature of ophthalmology and scientific pathology. regardless of its really basic constitution the cornea possesses many distinct houses. those attributes contain its crystal readability and avascularity within the future health country. This more often than not obvious constitution has been the point of interest for Dr. Klintworth's examine endeavors for greater than 20 years. This monograph summarizes present wisdom approximately angiogenesis inside of this tissue in addition to information regarding the similar factor of the cornea's common avascularity. The textual content offers a entire assessment of the subject in keeping with experiences by means of numerous investigators who have been both taken with corneal neovascularization specifically or angiogenesis in general.

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In 1947 Bachsich and Wyburn (36) proposed that corneal neovascularization was a sequel to the destruction of an anti-angiogenic factor which normally restrained neighboring vascular cells from invading the cornea. Corneal Edema Eliminating Mechanical Barrier In 1948 Mann, Pirie and Pullinger (496) made the important observation that blood vessels only invade the corneal stroma when the tissue is edematous. A year later Cogan (143) hypothesized that the edema was cardinal in the induction of the angiogenesis as it loosened the corneal stroma thereby permitting the ingrowth of vessels that had been restrained by the compact collagen bundles in the normal cornea.

Fibrin appears within the inflammatory exudate of vascularizing corneal tissue (524) and the invasion of corneal tissue by blood vessels is apparently enhanced by antifibrinolysins (epsilon-aminocaproic acid and BP 961) (708). Moreover, fibrin deposition consistently precedes new vessel growth in solid tumors and healing wounds (188) and fibrin degradation products induce angiogenesis in the chick chorioallantoic membrane (759). A fibrin gel around tumors progressively vascularizes (185-187) and subcutaneously implanted fibrin gels induce an angiogenic response in the absence of tumor cells and platelets (188).

Also, mast cell granules stimulate the proliferation of microvascular endothelial cells in culture (498). Rat mast cells also evoke an angiogenic response when implanted on the chick CAM (406). Because mast cells are present at the corneoscleral limbus, the possibility of them inhibiting corneal vascularization was raised several years ago by Smith (707), who proposed that their massive destruction following corneal injury caused blood vessels to invade the cornea. Mast cells infiltrate the cornea before blood vessels and have been implicated in capillary growth as part of the host response to bovine intralamellar heterografts in the rabbit (709).

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